Defending champions England took 4x100m relay gold when Ojie Edoburun anchored a slick screen.
Edoburun, who was called up to the team after Reece Prescod was forced out with an injury, finished in 38.35 seconds ahead of Trinidad and Tobago.
Jona Efoloko, 22, was favored over Adam Gemili in the opening race, with Zharnel Hughes and Nethaneel Mitchell-Blake impressing in the middle of the race.
The England women took silver behind Nigeria in the women’s version.
Led by Asha Philip, Imani Lansiquot and Bianca Williams delivered the baton in the final 100 meters with ground to overtake Nigeria.
Anchor Daryll Neita briefly threatened to bring in Nzubechi Grace Nwokocha when the crowd felt a dramatic comeback, but England got off track.
Nigeria won in 42.10, 0.31sec for the hosts.
Efoloko, a former Under-20 200m World Champion, was also with Mitchell-Blake and Hughes when Great Britain won world bronze in Eugene last month.
“I love it more and more. Second time, second medal. It’s a lot of pressure and you want to do it right,” he told BBC Sport.
He was waiting to hug Edoburun at the end of the race when the pair urged the crowd to make even more noise.
“I’m just so happy to come in and fit in well with the guys,” said Edoburun.
“I didn’t want to miss this special generation of athletes and I want to take this confidence to the Europeans.”